ATP Synthase Inhibitor

ATP Synthase Inhibitors (32):

Cat. No.	Product Name	Effect	Purity

HY-N6782

Oligomycin	Inhibitor	≥99.0%
Oligomycin, an antifungal antibiotic, is an inhibitor of H⁺-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells.

HY-16589

Oligomycin A	Inhibitor	99.94%
Oligomycin A (MCH 32), created by Streptomyces, acts as a mitochondrial F₀F₁-ATPase inhibitor, with a K_i of 1 μM; Oligomycin A shows anti-fungal activity.

HY-100542

D-α-Hydroxyglutaric acid disodium	Inhibitor	≥98.0%
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.

HY-111651

Gboxin	Inhibitor	98.23%
Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F₀F₁ ATP synthase. Antitumour activity.

HY-10250S1

Triciribine phosphate-d₃	Inhibitor
Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

HY-16589R

Oligomycin A (Standard)	Inhibitor

HY-136406

Bongkrekic acid	Inhibitor	≥99.0%
Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport.

HY-15877

BTB06584	Inhibitor	99.60%
BTB06584 is a selective and IF1-dependent mitochondrial F₁F_o-ATPase inhibitor without compromising ATP synthesis. BTB06584 can delays ischaemic cell death.

HY-112715

ATP synthase inhibitor 1	Inhibitor	99.73%
ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F₁/F_O-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels.

HY-109098

Parimifasor	Inhibitor	98.53%
Parimifasor (LYC30937) is an immunomodulator, with anti-inflammatory activity.

HY-126679

Apoptolidin	Inhibitor
Apoptolidin is a polyketide isolated from Nocardiopsis?bacteria. Apoptolidin is a selective mitochondrial F₁F_O ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC₅₀=10-17 ng/ml) but not in normal cells.

HY-136406S

Bongkrekic acid-¹³C₂₈	Inhibitor	≥98.0%
Bongkrekic acid-¹³C₂₈ is the ¹³C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport.

HY-N125722

Venturicidin A	Inhibitor
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

HY-148041

ATPase-IN-2	Inhibitor	≥98.0%
ATPase-IN-2 is an ATPase inhibitor with an IC₅₀ value of 0.9 μM. ATPase-IN-2 inhibits C. difficile toxin B (TcdB) glycohydrolase activity with an AC₅₀ value of 30.91 μM. ATPase-IN-2 can be used for the research of ATP-related.

HY-N6784

Oligomycin B	Inhibitor
Oligomycin B is an antibiotic isolated from marine Streptomyces, used as an eukaryotic ATP synthase inhibitor, induces apoptosis.

HY-146388

Mtb ATP synthase-IN-1	Inhibitor	98.55%
Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC₅₀ > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium.

HY-150983

ATP synthase inhibitor 2	Inhibitor	99.93%
ATP synthase inhibitor 2 is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC₅₀=10 μg/mL). ATP synthase inhibitor 2 can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL.

HY-148973

ZW290	Inhibitor	99.60%
ZW290 is a compound to activate brown adipose tissue (BAT) thermogenic function. ZW290 increases the expression of uncoupling Protein 1 (UCP1) protein and inhibits ATP synthesis in BAT.

HY-121908

FCPT	Inhibitor
FCPT, an ATP competitive inhibitor, induces a tight-binding of kinesin-5 onto microtubules and induced loss of microtubules selectively at the poles of Xenopus extract spindles without altering microtubule dynamics.

HY-168006

NSC819701	Inhibitor
NSC819701 is a triazole inhibitor of the p97 ATPase. NSC819701 inhibits the activity of p97 ATPase by binding to a specific site of p97.

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